Biomedical Engineering Reference
In-Depth Information
(a)
Light source
Detector
Light source
(b)
Detector
Light source
(c)
Detector
Sensing layer
Fig. 11.5.
Design principles for optrode biosensors. (
a
) Two fibers: one carries light
to the sensing layer and one carries the signal to the detector. (
b
) Bifurcated fiber:
the biosensing layer is placed on the fused end of the fiber. (
c
) The biosensing layer
is placed on the central fiber, and the surrounding fibers are used to collect the light
signals. Reprinted from [1] with permission from Elsevier
Fig. 11.6.
Schematic (
a
) and photograph (
b
) of injection-molded optical fiber
probes and fluidics coupon for use with the RAPTOR-Plus. (
a
and
b
from [1],
reprinted with permission from Elsevier). (
c
) Photograph of the Raptor Plus with
keypad control and result window on the
left
and the sample port and reagent
chamber on the
right
(Fig. 11.6). This system is proving to be very reliable in terms of long term
operation (¿3 years to date, George Anderson, personal communication). In
both the 4-probe Raptor and the more recently developed 8-fiber BioHawk,
a disposable coupon contains the fiber probes, providing protection dur-
ing long-term storage and fluidic channels for automated sample processing.
