Biomedical Engineering Reference
In-Depth Information
100
Si
80
Capable of detecting amount of analyte ~ 2.5 fg
60
40
20
0
0 0 0 0 0
50
60
70
Coating thickness
∆
t (nm)
Fig. 7.24.
Calculated resonance red shift vs coating thickness, for a biomolecule
layer on the side walls of the air holes, at the bottom of the air holes, or on top of
the device
Fig. 7.25.
Close up of near the central defect of a 2D PhC microcavity in which
one latex microsphere has been captured
one latex microsphere was inside the defect region and the rest of the spheres
remained on top of the device. The normalized transmission spectra of the
PhC microcavity shown in Fig. 7.26 demonstrate that the device can detect a
single bioparticle. For a device with a quality factor Q of
2,000, a spectral
shift of 1 nm can be measured very easily. Simulations show that biomolecules
smaller than 50 nm can be detected.
∼
