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Hormone-induced Protection
of Mammary tumorigenesisin
Models
Lakshmanaswamy Rajkumar, Frances S. Kittrell,
Raphael C. Guzman, Powel H. Brown, Satyabrata Nandi
and Daniel Medina
AbstrAct
Introduction
The experiments reported here address the question of whether a short-term
hormone treatment can prevent mammary tumorigenesis in two different ge-
netically engineered mouse models.
Methods
Two mouse models, the p53-null mammary epithelial transplant and the
c-neu mouse, were exposed to estrogen and progesterone for 2 and 3 weeks,
respectively, and followed for development of mammary tumors.
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