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A self-inactivating retrovector
incorporating the iL-2
Promoter for Activation-
induced transgene expression
in Genetically engineered
t-cells
Diana E. Jaalouk, Laurence Lejeune, Clément Couture and
Jacques Galipeau
AbstrAct
Background
T-cell activation leads to signaling pathways that ultimately result in induc-
tion of gene transcription from the interleukin-2 (IL-2) promoter. We hypoth-
esized that the IL-2 promoter or its synthetic derivatives can lead to T-cell
 
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