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marrow-derived mesenchymal stem cells showed cytogenetic aberrations after sev-
eral passages in vitro, which resulted in malignant lesions when infused to second-
ary recipients [32,33]. All of these contradictions indicated that the fate and effect
of BMSCs on tumor growth should be further investigated.
In conclusion, we demonstrated that BMSCs might be employed as a prom-
ising vehicle for tumor gene therapy which can effectively not only improve the
concentration of anticancer therapeutics in tumors, but also modify the tumor
microenvironment. However, the fate and effect on tumor growth of BMSCs
systemically administrated should be further evaluated.
competing interests
The authors declare that they have no competing interests.
Authors' contributions
JLY and YQW conceived of the study, and participated in its design and coordina-
tion. MH, JLY and HT participated in the design, cell experiment, animal experi-
ment and drafted the manuscript. XZ, YQJ, LT carried out the cell culture and
relevant analysis. RW, XWZ carried out the immunochemistry experiment, statis-
tical analysis. YW, YL carried out the mouse alginate test. XCC, RZ participated
in the pathologic analysis. All authors read and approved the final manuscript.
Acknowledgements
This work was supported by National Key Basic Research Program of China
(2004CB518800), Project of National Natural Sciences Foundation of China,
Natural 863 Projects.
references
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cells. Science 1999, 284:143-147.
2. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ:
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