Transplantation of Genetically Engineered Cardiac Fibroblasts Producing Recombinant Human Erythropoietin to Repair the Infarcted Myocardium - Genetic Engineering: Recent Developments in Applications - page 200

Table 3. (Continued)
Morhpometric analysis of the infarcted hearts showed that EPO-transduced
cell injection also fails to prevent infarct expansion and scar thinning (Table 4).
For major parameters (average scar thickness, LV cavity area, whole LV area and
expansion index), EPO-transduced cells showed significant adverse remodeling
compared to non-transduced cells with a magnitude similar to saline-treated ani-
mals. Furthermore, non-transduced cell injection attenuated infarct expansion
and preserved LV area, compared to saline-treated animals.
Table 4. Comparison of LV remodeling by postmortem morphometry, 9 weeks after MI