Biomedical Engineering Reference
In-Depth Information
Methyl Isocyanate
Regulatory, advisory
Health nembers
a
numbers
b
100
LC
50
(mice) (29 mg/m
3
)
LC
50
(rats) (14 mg/m
3
)
NIOSH IDLH (7 mg/m
3
)
10
NOAEL
c
(lung and
body weight
(1.4 mg/m
3
)
AIHA ERPG-2 (1 mg/m
3
)
1
AIHA ERPG-1 (0.06 mg/m
3
)
NIOSH REL,
OSHA PEL,
ACGIHTLV
(0.05 mg/m
3
)
0.1
0.01
CaIEPA
reference
exposure
level
(0.001 mg/m
3
)
0.001
0.0001
Figure
7.3
Health data for inhalation of methyl isocyanate (MIC).
Adapted from: US Environmental Protection Agency, 1986,
Health
and
Environmental
Effects
Profile
for
Methyl
Isocyanate
,
Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Devel-
opment, Cincinnati, OH; US Department of Health and Human Services, 1993, Hazardous Substances Data Bank (HSDB, online
database), National Toxicology Information Program, National Library of Medicine, Bethesda, MD; US Department of Health
and Human Services, 1993, Registry of Toxic Effects of Chemical Substances (RTECS, online database), National Toxicology
Information Program, National Library of Medicine, Bethesda, MD; California Environmental Protection Agency (CalEPA), 1997,
Technical Support Document for the Determination of Noncancer Chronic Reference Exposure Levels, Draft for Public Comment,
Office of Environmental Health Hazard Assessment, Berkeley, CA; US Environmental Protection Agency, 1999,
Integrated
Risk
Information
System
(IRIS)
on
Methyl
Isocyanate
, National Center for Environmental Assessment, Office of Research and Develop-
ment, Washington, DC; J.E. Amoore and E. Hautala, 1983, Odor as an Aid to Chemical Safety: Odor Thresholds Compared with
Threshold Limit Values and Volatilities for 214 Industrial Chemicals in Air and Water Dilution,
Journal
of
Applied
Toxicology
,
3 (6), pp. 272-90; National Institute for Occupational Safety and Health (NIOSH), 1997,
Pocket
Guide
to
Chemical
Hazards
,
US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Cincinnati,
OH; Occupational Safety and Health Administration (OSHA), 1998, Occupational Safety and Health Standards, Toxic and Haz-
ardous Substances,
Code
of
Federal
Regulations
29 CFR 1910.1000; American Conference of Governmental Industrial Hygienists
(ACGIH), 1999,
1999
TLVs
and
BEIs.
Threshold
Limit
Values
for
Chemical
Substances
and
Physical
Agents.
Biological
Exposure
Indices,
Cincinnati, OH; and American Industrial Hygiene Association (AIHA), 1998,
The
AIHA
1998
Emergency
Response
Planning
Guidelines
and
Workplace
Environmental
Exposure
Level
Guides
Handbook
.
