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(GAD), which is the database provided by NIH that includes diseases-related genes
and their detailed information.
Additionally, six pathways were identified by finding the KEGG pathways belong-
ing to
Acute myeloid leukemia pathway
, which include
hsa04640
,
hsa04010
(MAPK
signaling pathway),
hsa04630
(Jak-STAT signaling pathway),
hsa04210
,
hsa04150
(mTOR signaling pathway), and
hsa04110
.
Fig. 12.
The acute myeloid leukemia pathway appeared in KEGG pathway
Thus, by combining all of these pathways, we eventually collected 10 Leukemia-
related pathways in total, as shown in Table 1, which were used as gold standards for
the evaluation of our analysis results. Also, Table 2 shows the significant pathways on
the Leukemia dataset each identified by original GSEA and FC-GSEA, respectively. As
seen in this table, only the three pathways (hsa00480, hsa04110, hsa04640) were found
with original-GSEA, On the other hand, by using FC-GSEA, eight of the ten pathways
which include hsa00480, hsa00980, hsa04110, hsa04210, hsa04630, hsa04640,
Table 1.
10 Leukemia-related pathways collected by the authors
Fisher's exact
test
Acute myeloid
leukemia pathway
KEGG pathway names
Literatures
Glutathione metabolism
O
Metabolism of xenobiotics by
cytochrome P450
O
MAPK signaling pathway
O
Cell cycle
O
O
mTOR signaling pathway
O
Apoptosis
O
O
Jak-STAT signaling pathway
O
Hematopoietic cell lineage
O
O
T cell receptor signaling pathway
O
B cell receptor signaling pathway
O
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