Chemistry Reference
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Refer to the structures numbered 1 to 6 in Figure 3.25. In each case
select the form of the drug that predominates in human plasma at
pH 7.4:
(a)
Q3.2
Mono-cation
(b)
Di-cation
(c)
Mono-anion
(d)
Di-anion
(e)
Neutral molecule
O
C 2 H 5
1.
H 2 N
N
C 2 H 5
O
H
O
C 2 H 5
N
2.
O
N
C 2 H 5
O
H
O
3.
C 4 H 9
N
H
N
O
H
OH
H
O
N
Pr i
O
H 2 N
4.
CH 3 CH 2 OH
5.
O
O
6.
H
O
O
CH 3
Figure 3.25
Structures of drugs.
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