Chemistry Reference
In-Depth Information
Table 5.2
Continued
Drug
Pathway
Lovastatin
6
-Hydroxylation
HO
O
3
-Side-chain hydroxylation
3
-Hydroxylation
b
-Oxidation of lactone
O-glucuronides
O
O
CH
3
CH
2
O
H
3
C
CH
3
6
3
CH
3
Ciprofloxacin
Piperazine 3
-hydroxylation
O
N-sulfation
F
COOH
N
N
HN
Labetalol
O-sulfate (major)
O-glucuronide
CH
3
HO
N
H
H
2
N
C
OH
O
Paracetamol
O-glucuronide
O-sulfate
Oxidation to N-acetyl-p-benzoquinoneimine
Conjugation of N-acetyl-p-
benzoquinoneimine with glutathione
O
HN
CH
3
OH
(continued)
