Chemistry Reference
In-Depth Information
Table 5.2
Continued
Drug
Pathway
Phenmetrazine
Oxidation to lactam
Aromatic hydroxylation
N-oxidation
Conjugation of phenolic products
O
CH
3
N
H
Ephedrine
N-dealkylation
Oxidative deamination
Oxidation of deaminated product to
benzoic acid
Reduction of deaminated product to
1,2-diol
HO
CH
3
NHCH
3
Propranolol
Aromatic hydroxylation at C-4
CH
3
N-dealkylation
Oxidative deamination
Oxidation of deaminated product to
naphthoxylactic acid
Conjugation with glucuronic acid
O-dealkylation
N
H
CH
3
O
OH
4
Indometacin
O-demethylation
N-deacylation of p-chlorobenzoyl group
Both O-dealkylation and N-deacylation
Conjugation of phenolic products with
glucuronic acid
Other conjugation products
CH
3
O
COOH
N
CH
3
O
Cl
(continued)
