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Fig. 9.1 Placental TauT expression and activity are similar in first trimester and at term. ( a ) TauT
mRNA expression relative to a 40-week placental sample, designated the calibrator, included in
each run as an internal standard. The groups are early first trimester (6-9 weeks, n = 23), late fi rst
trimester (10-13 weeks, n = 12), and term (38-40 weeks, n = 21). ( b ) Western blot of first trimester
(F) and term placental (T) samples probed for TauT. A single immunoreactive species was detected
at the expected molecular weight of 70 kDa. Bar chart displays densitometric analysis of signal
intensity ( n =4 for each group, median and interquartile range). ( c ) Na + -dependent 3 H-taurine
uptake by first trimester ( open circles ) and term ( closed squares ) placental villous fragments ( n = 6
in each group; mean ± SE). At both gestations, 3 H-taurine uptake significantly increased with time
( p < 0.005; least square linear regression). There was no difference in 3 H-taurine uptake between
fi rst trimester and term placenta (2-way ANOVA)
Fig. 9.2 Placental STB TauT activity is negatively related to maternal BMI and reduced in
pre-eclampsia (PE). ( a ) Negative relationship between maternal BMI and TauT activity in first
trimester ( open circles , n = 12) and term ( closed squares , n = 12) placental villous fragments. Least
square linear regression; r 2 = 0.60 and 0.54, respectively, p < 0.01 for each. ( b ) TauT activity in
normal pregnancy (NP, n =9) and PE (PE, n =5) in women with BMI <30. p < 0.01: Mann
Whitney- U test
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