Biology Reference
In-Depth Information
25
Control
Captopril
δ
β
20
Tamoxifen
∗
15
δ
β
∗
ψ
β
#
∗
∗
10
ψ
β
ψ
β
β
∗
#
#
∗
5
#
0
CW
CG
TSW
TSG
TDW
TDG
Fig. 8.6
Comparison of insulin resistance among groups (
CW
control with water intake alone,
CW + Cap
CW plus captopril treatment,
CW + Tam
CW plus tamoxifen treatment,
CG
control with
high sugar intake,
CG + Cap
CG plus captopril treatment,
CG + Tam
CG plus tamoxifen treatment,
TDW
perinatal taurine depletion with water intake alone,
TDW + Cap
TDW plus captopril treat-
ment,
TDW + Tam
TDW plus tamoxifen treatment,
TDG
perinatal taurine depletion with high
sugar intake,
TDG + Cap
TDG plus captopril treatment,
TDG + Tam
TDG plus tamoxifen treat-
ment,
TSW
perinatal taurine supplementation with water intake alone,
TSW + Cap
TSW plus cap-
topril treatment,
TSW + Tam
TSW plus tamoxifen treatment,
TSG
perinatal taurine supplementation
with high sugar intake,
TSG + Cap
TSG plus captopril treatment,
TSG + Tam
TSG plus tamoxifen
treatment; *
p
< 0.05 compared to untreated control of same taurine status;
#
p
< 0.05 compared to
CW of same treatment;
b
p
< 0.05 compared to CG of same treatment;
d
p
< 0.05 compared to TDW
of same treatment;
y
p
< 0.05 compared to TSW of same treatment)
and insulin resistance in the present study in all groups except in CG animals.
Whether some diabetogenic factors including plasma catecholamine, cortisol,
glucagon, and growth hormone play a significant role in this case has to be further
investigated.
Perinatal protein malnutrition or taurine depletion induces glucose intolerance,
insulin resistance, and diabetes mellitus in adult offspring (Aerts and Van Assche
2002
). These changes coincide with a high risk of many cardiovascular disorders
particularly obesity, hypertension, and coronary vascular disease. The present
experiment confirms this finding. Perinatal taurine depletion induces mild hyper-
insulinemia and insulin resistance without hyperglycemia or glucose intolerance.
Acute inhibition of the RAS further increases insulin resistance in TDW while
RAS inhibition increases insulin resistance much more in TDG rats, suggesting
Search WWH ::
Custom Search