Biology Reference
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100
Control
Captopril
δ
∗
Tamoxifen
80
60
ψ
#
β
∗
∗
40
ψ
β
ψ
#
β
∗
∗
β
β
#
20
#
0
CW
CG
TDW
TDG
TSW
TSG
Fig. 8.4
Comparison of plasma insulin concentrations among groups (
CW
control with water
intake alone,
CW + Cap
CW plus captopril treatment,
CW + Tam
CW plus tamoxifen treatment,
CG
control with high sugar intake,
CG + Cap
CG plus captopril treatment,
CG + Tam
CG plus
tamoxifen treatment,
TDW
perinatal taurine depletion with water intake alone,
TDW + Cap
TDW
plus captopril treatment,
TDW + Tam
TDW plus tamoxifen treatment,
TDG
perinatal taurine deple-
tion with high sugar intake,
TDG + Cap
TDG plus captopril treatment,
TDG + Tam
TDG plus
tamoxifen treatment,
TSW
perinatal taurine supplementation with water intake alone,
TSW + Cap
TSW plus captopril treatment,
TSW + Tam
TSW plus tamoxifen treatment,
TSG
perinatal taurine
supplementation with high sugar intake,
TSG + Cap
TSG plus captopril treatment,
TSG + Tam
TSG
plus tamoxifen treatment; *
p
< 0.05 compared to untreated control of same taurine status;
#
p
< 0.05
compared to CW of same treatment;
b
p
< 0.05 compared to CG of same treatment;
d
p
< 0.05 com-
pared to TDW of same treatment;
y
p
< 0.05 compared to TSW of same treatment)
pancreatic damage induced by gestational protein malnutrition (Boujendar et al.
2002
; Merezak et al.
2001
) and can delay the onset of diabetes mellitus in non-
obese diabetic mice (Arany et al.
2004
). The present study indicates that perina-
tal taurine depletion induces mild insulin resistance without hyperglycemia or
glucose intolerance in adult female rats, an effect that is not heightened by high
sugar intake after weaning. However, short-term inhibition of RAS greatly
increases insulin resistance in rats that are perinatally taurine depleted and
receive a high sugar diet. Rats that receive perinatally taurine excess followed by
the high sugar intake show mild insulin resistance and moderate increase in insu-
lin resistance following RAS treatment in adult rats, and this increase is similar
in magnitude to that seen in control rats in response to RAS inhibition. Estrogen
inhibition causes moderate to no change in insulin resistance in rats that receive
perinatal taurine depletion or excess.
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