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Chapter 8
Perinatal Taurine Imbalance Alters
the Interplay of Renin-Angiotensin System
and Estrogen on Glucose-Insulin Regulation
in Adult Female Rats
Sanya Roysommuti , Atcharaporn Thaeomor , Sawita Khimsuksri ,
Wichaporn Lerdweeraphon , and J. Michael Wyss
Abstract Perinatal taurine depletion followed by high sugar intake (postweaning)
alters the renin-angiotensin system (RAS) and glucose regulation in adult female
rats. This study tests the hypothesis that in adult female rats, RAS and estrogen
contribute to insulin resistance resulting from perinatal taurine imbalance. Female
Sprague-Dawley rats were fed normal rat chow with 3% b-alanine (taurine deple-
tion, TD), 3% taurine (taurine supplementation, TS), or water alone (control, C)
from conception to weaning. Their female offspring were fed normal rat chow with
5% glucose in water (TDG, TSG, CG) or water alone (TDW, TSW, CW) throughout
the experiment. At 7-8 weeks of age, animals were studied with or without capto-
pril inhibition of the RAS and with or without estrogen receptor inhibition by
tamoxifen. Compared to CW and CG groups, perinatal taurine depletion but not
supplementation slightly increased plasma insulin levels. High sugar intake slightly
increased plasma insulin only in TSG. Captopril treatment significantly increased
plasma insulin in all groups except CG (the greatest increase was in TDG). Changes
in insulin resistance and insulin secretion paralleled the changes in plasma insulin
levels. In contrast, tamoxifen treatment increased insulin resistance and decreased
S. Roysommuti ( * ) ￿ W. Lerdweeraphon
Department of Physiology, Faculty of Medicine, Khon Kaen University,
Khon Kaen 40002 , Thailand
e-mail: sanya@kku.ac.th
A. Thaeomor
School of Physiology, Institute of Science, Suranaree University of Technology,
Nakhonratchasima 30000 , Thailand
S. Khimsuksri
Department of Oral Biology, Faculty of Dentistry, Khon Kaen University,
Khon Kaen 40002 , Thailand
J. M. Wyss
Department of Cell, Developmental and Integrative Biology, School of Medicine,
University of Alabama at Birmingham , Birmingham , AL 35294 , USA
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