Biology Reference
In-Depth Information
Chapter 6
Effect of Taurine Feeding on Bone Mineral
Density and Bone Markers in Rats
Mi-Ja Choi and Ji-Na Seo
Abstract
The purpose of this study was to investigate the effect of dietary taurine
supplementation on bone mineral density (BMD) and bone mineral content (BMC)
in rats. Twenty Sprague-Dawley male rats (body weight 200 ± 10 g) were divided
into two groups, control and taurine group (2% taurine-supplemented diet). All rats
were fed on experimental diet and deionized water and libitum for 6 weeks. Serum
alkaline phosphatase (ALP) activity, osteocalcin, PTH, and urinary deoxypyridino-
line cross-links value were measured as markers of bone formation and resorption.
BMD and BMC were measured using PIXImus (GE Lunar Co., Wisconsin) in spine
and femur. The effect of diet on ALP, osteocalcine, and PTH was not significant.
There were no significant differences in ALP, osteocalcine, and PTH concentration.
Urinary calcium excretion was lower in taurine group than in control group. Femur
BMC/weight of taurine group was significantly higher than control group. The results
of this study showed the possible role of taurine in bone metabolism in male rats.
Abbreviations
ALP
Alkaline phosphatase
DPD
Deoxypyridinoline
Tau
Taurine
DPD/Cr
Creatinine excretion
BMD
Bone mineral density
BMC
Bone mineral content
FER
Food ef fi ciency ratio
SBMD
Spine bone mineral density
M.-J. Choi (
*
) J.-N. Seo
Department of Food and Nutrition , Keimyung University ,
1000 Sindangdong, Dalseogu , Daegu 704-701 , South Korea
e-mail: choimj@kmu.ac.kr
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