Biology Reference
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16
14
12
10
8
Control
Ethanol
Taurine
E+T
*
6
4
2
0
Before 0.5 h
Time after the last taurine injection, h
Fig. 4.4 Drop in blood glucose in 5- to 6-month-old mice after taurine and ethanol coadministra-
tion. Control, n = 3; ethanol 8 g/kg, n = 3; taurine 10 g/kg, n = 3; E 8 g/kg +T 10 g/kg, n = 3
4.3.4
Changes in Blood Glucose Level After Taurine
and Ethanol Coadministration in Adult Mice
Adult mice treated with 10 g/kg taurine combined with 8 g/kg ethanol usually died
within 1 h after the last taurine injection. To measure the blood glucose level maxi-
mally close to death we assayed it 0.5 h after the last taurine injection. Two hours
before the treatment we measured the basic level of glucose. It was similar in all
experimental groups (8.5 ± 0.9 mmol/l), with individual variations from 7.5 to
11.1 mmol/l. Coadministration of taurine and ethanol significantly reduced the glu-
cose level from 9.3 ± 1.6 mmol/l to 5.6 ± 0.7 mmol/l (Fig. 4.4 ). Ethanol alone tended
to increase blood glucose, but the difference from 8.6 ± 0.2 mmol/l to 12.3 ± 2.1 mmol/l
was not statistically significant by reason of wide variation. Taurine alone did not
alter the blood glucose level.
4.3.5
Changes in Blood Glucose Level After Taurine
and Ethanol Coadministration in Old Mice
Old mice treated with 6 g/kg of taurine and 6 g/kg of ethanol died within 3-4 h after
the last taurine injection. We measured blood glucose at 1, 2, and 3 h after the last
taurine injection to monitor changes in blood glucose prior to death. Two hours
before the treatment the basic level of glucose was similar in all experimental groups
(8.5 ± 1.2 mmol/l), with individual variations ranging between 6.9 and 11.2 mmol/l.
Taurine and ethanol coadministration significantly lowered the glucose level from
 
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