Biology Reference
In-Depth Information
Table 4.1
Mouse mortality data
Death/number in a group
Adult mice
Ethanol, g/kg
Old mice
12
2/2
-
10
2/2
4/4
8
0/2
3/4
6
-
0/4
0
0/2
0/4
was no difference in lethality between males and females, we show total data on
lethality in both sexes. Taurine at a total dose of 4 g/kg co-administered with ethanol
at a total dose of 5 g/kg killed 58% of 7-day-old mice. An increase in taurine dose
to 6 g/kg administered to ethanol-treated mice induced 100% mortality (Fig. 4.1 ).
Though we monitored the mice for 14 days after treatment to detect any signs of
toxicity, they usually died during the first hours after the last taurine injection.
All mice exposed to ethanol or taurine alone and mice treated with 2 g/kg taurine
co-administered with 5 g/kg ethanol survived.
4.3.2
Combined Toxicity of Taurine and Ethanol in Adult Mice
In the first set of experiments on adult (5 to 6 months old) mice we established that
the total dose of ethanol 8 g/kg administered in two half-doses with a 2-h interval
was the maximal dose not lethal for mice of this age (Table 4.1 ). Coadministration
of taurine at a dose of 8 g/kg with ethanol (8 g/kg) killed 50% of the adult mice. One
hundred % lethality was observed at a taurine dose of 10 g/kg administered to etha-
nol-treated mice (Fig. 4.2 ). All mice treated with taurine or ethanol alone at the
doses used survived for the 14 days of observation. All those treated with 6 g/kg
taurine co-administered with 8 g/kg ethanol likewise survived.
4.3.3
Combined Toxicity of Taurine and Ethanol in Old Mice
In the preliminary experiments on old (12 to 13 months old) mice we found the total
dose of ethanol 6 g/kg administered in two half-doses with a 2-h interval to be the
maximal dose not lethal for mice of this age (Table 4.1 ). Testing different taurine
doses co-administered with 6 g/kg of ethanol we found taurine at a dose of 4 g/kg
administered to the ethanol-exposed mice to kill 22% of treated mice. Taurine at a
total dose of 6 g/kg combined with 6 g/kg ethanol resulted in 69% mortality
(Fig. 4.3 ). All mice treated with taurine or ethanol alone survived the whole 14-day
period of observation.
 
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