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alcohol intake. These results suggested that taurine administered alone or together
with Chinese traditional medicine could significantly decrease the blood concentra-
tion of alcohol, while taurine coadministration with Chinese traditional medicine
had better effects than taurine alone.
Because the metabolism processes of alcohol were activated in the liver, espe-
cially the ADH pathway, hepatic activities of ADH and ALDH increased after
alcohol intake. In the present study, both ADH and ALDH activities in 2% taurine
and T+CTM groups were significantly increased, suggesting that taurine added
alone or together with Chinese traditional medicine could accelerate the metabolism
of alcohol by way of increasing the activities of ADH and ALDH in the liver, so
alcohol could be quickly oxidized into acetaldehyde which could also be catalyzed
by ALDH into acetic acid, and finally changed into CO 2 and H 2 O 2 . In this way,
taurine and Chinese traditional medicine could obviously reduce the concentrations
of alcohol and its metabolic products in the liver as well as in the blood so as to
reduce the injury to the liver and the brain caused by these chemicals, which could be
obviously seen from the antialcohol intoxication results in this study, and taurine
coadministered with Chinese traditional medicine had better effects.
3.5
Conclusion
In summary, this study showed that supplementation of taurine could accelerate the
metabolism of alcohol and reduce the toxicity of alcohol, and taurine coadministration
with Chinese traditional medicine had better effects.
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