Biology Reference
In-Depth Information
3.2.4
Statistical Analysis
Values are mean ± SEM. Comparisons were performed by one-way analysis of
variance (ANOVA), followed by Tukey's post hoc test. Differences were consid-
ered statistically significant when the calculated P value was less than 0.05.
3.3
Results
3.3.1
Antialcohol Intoxication Effects of Taurine
and Chinese Traditional Medicine
In this study, we examined the effects of taurine and Chinese traditional medicine
supplementation on alcohol intoxication. There were 10 mice in each group at the
beginning of the experiment, while after alcohol intake, 10 mice were intoxicated in
group I and IV, 9 mice were intoxicated in group II and V, only 5 mice were intoxi-
cated in group III. Tolerance time in group II and III was significantly longer than
group I (
P
< 0.05,
P
< 0.01), while maintenance time in group II and III was
significantly shorter than group I (
P
< 0.05,
P
< 0.01); there were no significant
differences between group II and III (
P
> 0.05). Tolerance time in group V and VI
was extremely longer than group IV (
P
< 0.01); maintenance time in group V and
VI was obviously shorter compared with group IV (
P
< 0.01) (Fig.
3.1
).
3.3.2
Taurine and Chinese Traditional Medicine Decreased
Blood Concentration of Alcohol
As shown in Fig.
3.2
, there were no significant differences in blood concentrations
of alcohol among all the groups 20 min after alcohol intake (
P
> 0.05). From the
50 min point, the values in T+CTM group decreased very significantly at each time
point (
P
< 0.01), while those in the 2% Tau group declined obviously at 50, 120, and
150 min, extremely significant at 90 min compared with the values in the control
group (
P
< 0.01). The peak points of alcohol concentrations in each group were
90, 50, and 20 min, respectively.
3.3.3
Taurine and Chinese Traditional Medicine Increased
Activities of ADH and ALDH in the Liver
As shown in Fig.
3.3
, hepatic activities of ADH and ALDH increased with time
changing, especially in T+CTM and 2% taurine groups, the values of which were
significantly higher compared with the control group (
P
< 0.05). The activities of
ADH and ALDH both reached the peak at 150 min point.
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