Knockdown of TauT Expression Impairs Human Embryonic Kidney 293 Cell Development - Advances in Experimental Medicine and Biology - page 297

Marker Mock TauT-deficient

DOX (ng/ml) 0 100 200 0 100 200

Fig. 28.5 TauT deficiency renders renal cell more sensitive to doxorubicin-induced apoptosis.
Cells were treated with doxorubicin (0-200 ng/ml). The DNA isolated from TauT-deficient cells
produced a highly distinguished ladder pattern, demonstrating that a significant percentage of
TauT-deficient cells underwent apoptosis. Under the same environmental stress, the degree of cell
death in the mock culture was not significant enough to produce the characteristic “ladder”
appearance

Fig. 28.6 Flow cytometry analysis of cell proliferation. Control and TauT-deficient 293 cells were
treated with or without cisplatin (25 mM) for 24 h, and then cells were stained with IP for cycle
analysis