Biology Reference
In-Depth Information
Table 25.2 Comparison of mobility after drug
treatment
Conc.( m g/ml)
0
Drug
10
100
Astressin-B
+
++
+
Finasteride
+
+
++
Tau
+
++
+++
Tun-only
+
+
+
recover from the ER stress at the level of organism. The increased number of
offspring may originate from the anti-ER stress effect of the three candidate
molecules.
25.3.4
Restoration of Mobility Among Worms Treated
with Anti-Alopecia Agents
To evaluate the effect of anti-alopecia agents on the mobility of the stressed worms,
their moving distances were figured out according to the turbidity which was caused
by the worm's path. The turbidity was visually compared at three different concen-
trations of the candidate chemicals. When treated with Tun, worms showed a con-
siderable decline in mobility. The reduced movement of worms, however, apparently
recovered to reach the level of ER stress-free control when worms were treated with
taurine or two other alopecia agents following taurine application. Table 25.2 sum-
marizes the mobility of worms cultured at two different concentrations of the three
drugs, as expressed in the turbidity of the media. Along with astressin-B and
finasteride, taurine facilitates the worms to recover from the stress. This result
strongly implies that taurine helped the worms recuperate from the adverse influence
of ER stress on their mobility.
25.4
Discussion
A considerable percentage of adults and youths suffer severe emotional stress
from alopecia. Alopecia occurs in adolescents even at the age of 14. Astressin-B
and finasteride cannot be applied to the adolescents less than 18 years old and
hair implant is not a feasible alternative at this age, and development of safe anti-
alopecia agents is very important under the circumstances. The present study
utilized C . elegans to develop an assay system for anti-alopecia drugs which are
especially effective against stresses.
C . elegans displayed usual ER stress signs under tunicamycin with treatment
such as augmented expression of hsp-70, heat shock proteins. The tunicamycin
Search WWH ::




Custom Search