The Mechanism of Taurine Protection Against Endoplasmic Reticulum Stress in an Animal Stroke Model of Cerebral Artery Occlusion and Stroke-Related Conditions in Primary Neuronal Cell Culture - Advances in Experimental Medicine and Biology - page 239

Fig. 23.5 Schematic diagram showing the mode of action of taurine in alleviating the apoptosis induced
by ER stress and mitochondrial dysfunction. Taurine can exert its regulation by decreasing GRP78
release, caspase-12 activity, Bax, caspase-3, p-IRE1, ATF6 cleavage, CHOP, and increasing Bcl-2

of both CHOP and caspase-12 by taurine treatment provide substantial evidence
that taurine can contribute to an effective inhibition of ER stress induced by hypoxia/
reoxygenation.

23.5 Conclusion

In summary, as it is shown in Fig. 23.5 , we demonstrated that taurine can exert its
protective effect on CNS neurons both in the in vitro model of hypoxia/reoxygen-
ation and in vivo model of the MCAO through suppression of ER stress. Moreover,
the effect of taurine treatment on the three ER stress-induced signaling pathways
showed that taurine significantly inhibited apoptosis by activation of the ATF6 and
the IRE1 pathway, but not the PERK pathway.

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