Effects of Taurine on Myocardial cGMP/cAMP Ratio, Antioxidant Ability, and Ultrastructure in Cardiac Hypertrophy Rats Induced by Isoproterenol - Advances in Experimental Medicine and Biology - page 208

4

Control
Model
P

3.5

PII
PIII

* *

*

3

* *

* *

2.5

2

* *

1.5

1

0.5

0

GSH (mg/gprot) T-AOC (U/mgprot) MDA (nmol/mgprot)

400

*

Control
Model
P

350

300

P

250

II

200 P III

150

100

50

0

GSH·Px (U) SOD U/mgprot ʣ

Fig. 21.3 Effects of taurine on myocardium levels of GSH and MDA and activities of GSH.Px,
SOD, and T-AOC in rats. Results are presented as mean ± SE ( n = 5). *: significantly different from
the model group ( p < 0.05), **: significantly different from the model group ( p < 0.01)

increased by 3.68% and 15.78%, respectively; the levels of GSH-Px and T-AOC
were decreased, but showed no significant changes compared with control group.
Whereas taurine administration could significantly decrease the level of MDA and
obviously increase the levels of GSH and T-AOC, but had no effects on the levels of
SOD and GSH-Px compared with the model group.

21.3.4 Taurine Obviously Increases Serum Antioxidant

Ability in Cardiac Hypertrophy Rats

As shown in Fig. 21.4 , the levels of SOD, GSH-Px, and T-AOC were significantly reduced
by isoproterenol administration ( p < 0.01, p < 0.05, p < 0.01), but the levels of GSH and
MDA showed no significant changes compared with control group. However, administra-
tion of taurine could significantly increase the levels of SOD, GSH-Px, GSH, and T-AOC
and significantly decrease the level of MDA compared with the model group.