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21.3
Results
During the experimental period, the overall mortality was two rats in ISO group; no
death occurred in the other group's rats.
21.3.1
Taurine Decreases the Heart Coef fi cient and Serum
CK-MB Level in Cardiac Hypertrophy Rats
The effects of taurine on heart coefficient and serum CK-MB level were presented
in Fig. 21.1 . The heart coefficient was significantly increased when treated with
isoproterenol compared with control group ( p < 0.01) while three concentrations of
taurine obviously prevented the isoproterenol-induced increase in the heart
coef fi cient ( p < 0.05, p < 0.05, p < 0.01), but not in a dose-dependent manner.
The level of serum CK-MB was increased significantly by isoproterenol, 200 mg/kg
taurine decreased significantly the serum CK-MB compared with model group
( p < 0.05), but 100 mg/kg and 300 mg/kg taurine had no significant effect.
21.3.2
Taurine Decreases Myocardial cAMP and cGMP Levels
and Increases the Ratio of Myocardial cGMP/cAMP
in Cardiac Hypertrophy Rats
The effects of taurine on myocardial cAMP and cGMP levels and cGMP/cAMP ratio
were presented in Fig. 21.2 . The levels of cAMP and cGMP in myocardium were
increased extremely by isoproterenol compared with control group ( p < 0.01); 100 mg/
kg and 200 mg/kg taurine significantly decrease the levels of cAMP and cGMP com-
pared with model group ( p < 0.01, p < 0.01). However 300 mg/kg taurine could
significantly decrease the level of cAMP ( p < 0.01) but has no effects on the level of
cGMP compared with model group. After analyzing the data of cGMP/cAMP ratio,
we can see that isoproterenol caused the ratio of cGMP/cAMP to decline significantly
compared to control rats ( p < 0.05), while all the three concentrations of taurine obvi-
ously prevented the isoproterenol-induced diminution in the ratio of cGMP/cAMP in
myocardium ( p < 0.01, p < 0.01, p < 0.01), but there was not dose-dependent manner.
21.3.3
Taurine Increases Myocardial Antioxidant
Ability in Cardiac Hypertrophy Rats
As shown in Fig. 21.3 , the level of MDA was significantly increased by isoprotere-
nol administration ( p < 0.05). In model group the levels of SOD and GSH were
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