Comparative Evaluation of the Effects of Taurine and Thiotaurine on Alterations of the Cellular Redox Status and Activities of Antioxidant and Glutathione-Related Enzymes by Acetaminophen in the Rat - Advances in Experimental Medicine and Biology - page 199

present results and those gathered in an early study with TAU and HTAU, it is
apparent that the protection rendered by these sulfur-containing compounds is
highly dependent on the sulfur-containing functionality and that their protective
effect against APAP hepatotoxicity is the result of an antioxidant action that trans-
lates into reduced LPO, preservation of antioxidant defenses, and maintenance of
enzymatic mechanisms needed for GSH redox cycling, synthesis, and utilization.
When ranked according to their relative protective potencies, TTAU was more akin
to NAC and somewhat more effective than TAU.
Overall, the sulfinate analog of 2-aminoethane HYTAU appears to be a better
antioxidant than either the thiosulfonate or sulfonate analogs.
References
Acharya M, Lau-Cam CA (2010) Comparison of the protective actions of N-acetylcysteine, hypo-
taurine and taurine against acetaminophen-induced hepatotoxicity in the rat. J Biomed Sci
17(Suppl 1):S35
Adams JD, Lauterburg BH, Mitchell JR (1983) Plasma glutathione and glutathione disulfide in the
rat: regulation and response to oxidative stress. J Pharmacol Exp Ther 227:749-754
Adamson GM, Harman AW (1989) A role for the glutathione peroxidase/reductase enzyme system
in the protection from paracetamol toxicity in isolated mouse hepatocytes. Biochem Pharmacol
38:3323-3330
Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121-126
Akai S, Hosomi H, Minami K, Tsuneyama K, Katoh M, Nakajima M, Yokoi T (2007) Knock down
of g-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity. J Biol
Chem 282:23996-24003
Bessems JG, Vermeulen NP (2001) Paracetamol (acetaminophen)-induced toxicity: molecular and
biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol 31:55-138
Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302-310
Cotter MA, Thomas J, Cassidy P et al (2007) Melanoma in mice stress/damage and delays onset
of ultraviolet-induced N-acetylcysteine. Clin Cancer Res 13:5952-5958
Chung LJ, Tong MJ, Busuttil RW, Hiatt JR (2009) Acetaminophen hepatotoxicity and acute liver
failure. J Clin Gastroenterol 43:342-349
Duong CD, Loh JY (2006) Basic review. Laboratory monitoring in oncology. J Oncol Pharm Pract
12:223-236
Egawa M, Kohno Y, Kumano Y (1999) Oxidative effects of cigarette smoke on the human skin. Int
J Cosmet Sci 21:83-98
Gossai D, Lau-Cam CA (2009) The effects of taurine, taurine homologs and hypotaurine on cell
and membrane antioxidative system alterations caused by type 2 diabetes in rat erythrocytes.
Adv Exp Med Biol 643:359-368
Flohé L, Günzler WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105:114-121
Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in
mercapturic acid formation. J Biol Chem 246:7130-7139
Hayes JD, Strange RC (1995) Potential contribution of the glutathione S-transferase supergene
family to resistance to oxidative stress. Free Radic Res 22:193-207
Henderson CJ, Wolf CR, Kitteringham N, Powell H, Otto D, Park BK (2000) Increased resistance
to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase P i . Proc Natl Acad
Sci USA 97:12741-12745
Hinson JA, Roberts DW, James LP (2010) Mechanisms of acetaminophen-induced liver necrosis.
Handb Exp Pharmacol (196):369-405