Comparative Evaluation of the Effects of Taurine and Thiotaurine on Alterations of the Cellular Redox Status and Activities of Antioxidant and Glutathione-Related Enzymes by Acetaminophen in the Rat - Advances in Experimental Medicine and Biology - page 193

0.9 4

0.8

0.7

Liver
Plasma

3

0.6

0.5

2

0.4

0.3

1

0.2

0.1

0 0

Control NAC TAU TTAU APAP NAC +

APAP

TAU +
APAP

TTAU +
APAP

Fig. 20.3 The effects of NAC, TAU, and TTAU on liver and plasma GSSG levels of rats treated with
a hepatotoxic (800 mg/kg i.p.) dose of APAP. Differences were significant from control at * p < 0.05
and ** p < 0.01 and from APAP at † p <0.05 and †† p <0.01. Values are shown as mean ± SEM for n = 6

100

35

Liver
Plasma

90

30

80

25

70

60

20

50

15

40

30

10

20

5

10

0

0

Control NAC TAU TTAU APAP NAC +

APAP

TAU +
APAP

TTAU +
APAP

Fig. 20.4 The effects of NAC, TAU, and TTAU on the liver and plasma GSH/GSSG ratios of rats
treated with a hepatotoxic (800 mg/kg i.p.) dose of APAP. Differences were significant from con-
trol at * p < 0.05, ** p < 0.01, and *** p < 0.001 and from APAP at † p <0.05, †† p <0.01, and ††† p < 0.001.
Values are shown as mean ± SEM for n = 6