Comparative Evaluation of the Effects of Taurine and Thiotaurine on Alterations of the Cellular Redox Status and Activities of Antioxidant and Glutathione-Related Enzymes by Acetaminophen in the Rat - Advances in Experimental Medicine and Biology - page 191

Table 20.1 Effects of NAC, TAU, and TTAU on plasma activities of ALT, AST, and LDH of rats
when given in the absence or presence of a hepatotoxic (800 mg/kg i.p.) dose of APAP
Group ALT, U/L AST, U/L LDH, U/L
Control 40.55 ± 0.89 69.23 ± 4.91 507.82 ± 11.95
NAC 40.04 ± 1.06 71.39 ± 3.50 510.38 ± 5.06
TAU 39.95 ± 1.80 68.13 ± 4.62 480.38 ± 5.49
TTAU 40.13 ± 1.61 70.11 ± 4.12 465.17 ± 6.85
APAP 66.50 ± 1.53*** 162.40 ± 5.13*** 1992.76 ± 89.54***
NAC + APAP 48.98 ± 1.06* ,† 88.35 ± 6.23* ,††† 810.85 ± 115.75*** ,†††
TAU + APAP 54.78 ± 1.34* ,† 96.22 ± 4.28* ,††† 1030.71 ± 58.1*** ,††
TTAU + APAP 53.30 ± 2.04** ,† 92.43 ± 4.87** ,†† 1036.43 ± 54.21*** ,†††
Values are the mean ± SEM for n = 6. Differences were significant from control at * p < 0.05,
** p < 0.01, and *** p < 0.001 and from APAP at † p < 0.05, †† p < 0.01 and ††† p < 0.001

2.5 9

Liver
Plasma

8

2

7

6

1.5

5

4

1

3

2

0.5

1

0 0

Control NAC TAU TTAU APAP NAC +

APAP

TAU +
APAP

TTAU +
APAP

Fig. 20.1 The effects of NAC, TAU, and TTAU on liver and plasma MDA levels of rats treated
with a hepatotoxic (800 mg/kg i.p.) dose of APAP. Differences were significant from control at
* p < 0.05 and *** p < 0.001 and from APAP at †† p < 0.01 and ††† p <0.001. Values are shown as
mean ± SEM for n = 6

APAP markedly raised the MDA level in the plasma (by >200%) and liver (by
>130%). Both TAU and TTAU were able to attenuate these increases, with TTAU
appearing more potent (+48%, p < 0.01, and +14%, respectively) than TAU (+91%,
p < 0.001, and +22%, p < 0.05, respectively). On the other hand, NAC was more
potent than either TAU or TTAU especially in the plasma (32%, p < 0.01, and 16%,
p < 0.05, respectively).