Taurine Enhances Anticancer Activity of Cisplatin in Human Cervical Cancer Cells - Advances in Experimental Medicine and Biology - page 183

single treatment of taurine or cisplatin and co-treatment of cisplatin with taurine
induced apoptosis via expression of caspase-3 rather than PARP expression.
This study suggests that combination treatment of cisplatin with taurine enhanced
anticancer activity and reduced side effects of cisplatin by lowering the dose of
anticancer drugs.

19.5 Conclusion

In this study, we investigated anticancer effects of taurine and synergy effects of
taurine and cisplatin in human cervical cancer HeLa cells. Cell proliferations were
decreased in a dose-dependent manner, and co-treatment of cisplatin with taurine
was more effective than single treatment. Apoptotic cells were increased by treat-
ments of cisplatin with taurine. Induction of apoptosis was related to p53 expression
and caspase-3, caspase-6, caspase-7, and caspase-9. The present study suggests that
co-treatment of cisplatin with taurine enhanced anticancer effects of cisplatin
through apoptosis induction in HeLa cells.

Acknowledgements This research was supported by the Sookmyung Women's University
Research Grants 2010.

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