Additional Effects of Taurine on the Bene fi ts of BCAA Intake for the Delayed-Onset Muscle Soreness and Muscle Damage Induced by High-Intensity Eccentric Exercise - Advances in Experimental Medicine and Biology - page 172

Fig. 18.4 Serum lactate dehydrogenase (LDH) activity level and areas under the curve (AUC)
throughout the experimental period. Abbreviations : LDH lactate dehydrogenase, AUC area under
the curve of VAS during the experimental period, Before before exercise, After after exercise,
PLCB placebo supplement group, BCAA BCAA supplement group, TAU taurine supplement
group, AdTb addition of taurine with BCAA supplement group. Values are expressed in mean ± S.E.
* P < 0.05 and **P < 0.01 vs. Before (repeated measures ANOVA followed by the Dunnett's mul-
tiple comparison post hoc test ). ‡ P < 0.05 vs. PLCB (one-way ANOVA multiple comparison and
nonparametric Wilcoxon tests)
effect on DOMS. However, Shimomura et al. ( 2006 ) demonstrated that DOMS after
squat exercise was significantly reduced by only a single supplement of BCAA
(77 mg/kg) in females but not in males. This result attributed the difference to the
fact that females ingested a larger amount of BCAA relative to their muscle mass
compared with males. In the present study, the total amounts of BCAA intake per
body weight were smaller than the aforementioned study (Shimomura et al. 2006 ) :
45 and 51 mg/kg in the BCAA and AdTB groups, respectively. Therefore, the dose
of BCAA in each ingestion relative to individual muscle mass may be a key point
for attenuation of DOMS rather than the supplemental duration.
In this study, the duration of oral TAU administration as 6.0 g/day prior to exer-
cise was two weeks, and consequently, plasma TAU concentration was significantly
increased in the TAU and AdTB groups (data not shown). Previously, we have
already confirmed in human that oral TAU administration as 6.0 g/day for a week
significantly increased plasma TAU concentration (Ishikura et al. 2008 ) .
Furthermore, our previous data have shown that skeletal muscle TAU content was
enhanced when blood TAU level was increased by TAU administration (Ishikura
et al. 2011 ; Miyazaki et al. 2004a ; Yatabe et al. 2003 ). Thereby, it is suggested that
the present protocol of oral TAU supplementation might lead to increased TAU
content in the skeletal muscles. In contrast to BCAA supplementation, a certain