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14.5
Conclusion
In conclusion, our data indicate that ER stress is present in the liver from protein-
malnourished mice and this could be a risk factor for the development of insulin
resistance and type 2 diabetes in later life. TAU supplementation increases insulin
secretion capacity and reduces ER stress proteins in pancreatic islets and in the liver
possibly through increased Akt and ERK 1/2 activation.
Acknowledgements
This study was supported by grants from Fundação de Amparo à Pesquisa
do Estado de São Paulo (FAPESP), Conselho Nacional para o Desenvolvimento Científico e
Tecnológico (CNPq), and Instituto Nacional de Ciência e Tecnologia (INCT).
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