Biology Reference
In-Depth Information
Abbreviations
BMI
Body mass index
TG
Triglyceride
TC
Total cholesterol
LDL-C
Low-density lipoprotein-cholesterol
HDL-C
High-density lipoprotein-cholesterol
HPLC
High-performance liquid chromatography
ELISA
Enzyme-linked immunosorbent assay
RIA
Radio immune assay
12.1
Introduction
Obesity is an international health problem with major cause of morbidity, related
with an increased risk of metabolic syndrome and cardiovascular disease, and
various cancers. Excessive accumulation of intra-abdominal fat contributes to the
impairment of lipid metabolism in human obesity (Fujioka et al.
1987
) and is
fundamental to the pathogenesis of the metabolic syndrome with deregulating
adipokines such as adiponectin and leptin. Adiponectin acts as an anti-athero-
genic plasma protein and an endogenous modulator in vascular remodeling
(Ouchi et al.
2003
). Leptin inhibits food intake and decreases body weight and fat
store. Recent study suggests that taurine (2-aminoethane sulfonic acid) supple-
mentation interrupts vicious circle promoting obesity and may prevent
obesity(Tsuboyama-Kasaoka et al.
2006
). The purpose of this study was to inves-
tigate the relationship among serum taurine level, serum adipokine level, and
body composition during 8-week human body weight control program in Korean
obese female college students.
12.2
Methods
12.2.1
Study Subjects
Study subjects (22 female college students aged between 19 and 24 years) were
recruited from a university located in Incheon, Korea. All of the subjects submitted
to researcher written informed consent to take part in an 8-week body weight con-
trol program. The subjects were free-living and they ate self-selected food. No med-
icine or other nutritional supplements were taken. The study was conducted from
May to July in 2010. Result analysis was conducted for the 18 students who com-
pleted the 8-week program (drop rate: 18.2%). None of the women had any chronic
disease and all were free of any medication.
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