Positive Correlation Between Serum Taurine and Adiponectin Levels in High-Fat Diet-Induced Obesity Rats - Advances in Experimental Medicine and Biology - page 100

Chapter 11
Positive Correlation Between Serum Taurine
and Adiponectin Levels in High-Fat
Diet-Induced Obesity Rats

Jeong Soon You , Xu Zhao , Sung Hoon Kim , and Kyung Ja Chang

Abstract The purpose of this study was to investigate the relationship between
serum taurine level and serum adiponectin or leptin levels in high-fat diet-induced
obesity rats. Five-week-old male Sprague-Dawley rats were randomly divided into
three groups for a period of 8 weeks (normal diet, N group; high-fat diet, HF group;
high-fat diet + taurine, HFT group). Taurine was supplemented by dissolving in feed
water (3% w/v), and the same amount of distilled water was orally administrated to
N and HF groups. In serum, adiponectin level was higher in HFT group compared
to HF group. The serum taurine level was negatively correlated with serum total
cholesterol (TC) level and positively correlated with serum adiponectin level. These
results suggest that dietary taurine supplementation has beneficial effects on total
cholesterol and adiponectin levels in high-fat diet-induced obesity rats.

Abbreviations

N Normal diet

HF High-fat diet

HFT High-fat diet + taurine

E-fat Epididymal fat

R-fat Retroperitoneal fat

TG Triglyceride

TC Total cholesterol

HDL-C High-density lipoprotein-cholesterol

BW Body weight

J. S. You ￿ X. Zhao ￿ K. J. Chang ( * )
Deptartment of Food and Nutrition , Inha University , Incheon , South Korea
e-mail: [e-mail]
S. H. Kim
Department of Chemistry , Konkuk University , Seoul , South Korea