Agriculture Reference
In-Depth Information
Figure 2.2.
Influence of mass window setting for detection of 0.01mg/kg phosalone (
t
R
=
4.11min;
m
/
z
182.001) in apple baby food extract prepared with the QuEChERSmethod. Using a 1 Da mass window gave
peak-to-peak signal-to-noise (S/N) ratio of 6, but setting the mass window to 0.1 Da or even as low as
0.02 Da led to a S/N of 25 and 74, respectively. Ref. [9], Figure 3, p. 288. Reproduced with permission of
Elsevier Science Ltd.
of full spectral information even at very low levels without spectral deconvolution
(Figure 2.2) [11].
2.2.2 Liquid Chromatography-Mass Spectrometry
2.2.2.1 Advanced Column Techniques
Ultrahigh-Performance Liquid Chromatography (UHPLC) and Sub-2
μ
m
Columns
The basic concepts behind rapid analyses performed by high-performance
liquid chromatography (HPLC) have not changed since HPLCwas invented. What has
changed is the development of better separation media (i.e., available columns) and
