Agriculture Reference
In-Depth Information
GC
MS methods can be considered as high-throughput analyses because
one way to calculate sample throughput is to use the following equation [15]:
-
MS or LC
-
screening capacity
number of samples
total analysis time
sample throughput
(1.1)
where screening capacity or analysis capacity
number of target analytes that can be
screened or analyzed by the method; total analysis time
=
time for sample preparation
=
instrument data acquisition
data analysis (data process)
documentation. Given
+
+
+
this de
nition, analyses using GC
-
MS and LC
-
MS as already discussed can qualify
as
because their screening capacities can be, in some instances,
quite high. High screening capacities eliminate the need for many analyses on the
same sample that simply screen for just one or two analytes at a time. Practically, as
long as the sample throughput of a new method is signi
“
high throughput
”
cantly higher than that
obtained using the current prevailing method, the new method should be considered
as a high-throughput method.
1.1.5 Scope of the topic
Food safety analysis usually involves the simultaneous measurement of multiple
analytes from a complex matrix. Separation of the analytes from matrices is often
crucial for mass spectrometry-based analyses. Although separations can be achieved
electrophoretically on one- and two-dimensional gels, by capillary electrophoresis
and by GC and LC, both LC and GC are still the most applied separation methods
due to their good reproducibility,
recovery, sensitivity, dynamic range, and
quanti
ability [8,16].
MS has been widely used for food safety analysis for a long time. However,
the use of LC
GC
-
fields in
science and industry [17]. Currently, both LC-MS and GC-MS are widely used for
every food safety issue, as already mentioned. There are many modern approaches in
LC
-
MS for food safety analysis is among the fastest developing
-
MS- and GC
-
MS-based methods that enable the reduction of
“
analytical
”
time
and increase the sample throughput.
The topic is divided into eight chapters: Chapters 1
3 discuss technology back-
ground, statistical background, industrial standards, and governments
-
'
regulations.
Chapters 4
fields of method development, applications of new
technologies, and practice of analytical work to compile industrial standards and
government regulations. The topics include pesticide residues analysis, veterinary
drug residue analysis, mycotoxins analysis, and industrial chemical analysis. The
discussions will show not only the current dynamic interaction between technology
development and laboratory practice but also the trends of food safety analysis.
Advanced sample preparation techniques and future perspectives will be discussed in
the following sections, with an emphasis on an evaluation of or improvements in the
throughput of the methods.
-
8 discuss speci
c
