Simulation of Osteoporotic Bone Remodeling - Computational Biomechanics of the Musculoskeletal System - page 340

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FIgure 25.4 Simulation results of cortical thickness of tibia and femur models. The curves representing
cortical thickness are the simulation outcomes. (a) Tibia model and (b) femur model. (Data from Eser et al.,
Bone , 34, 869-80, 2004.

marrow. This removal causes a “disuse-pattern” osteopenia characterized by widening of the mar-
row cavities and thinning of cortical bone, as well as enlarged pores and thinning and fracture of
the trabeculae of cancellous bone. This is the physiological basis for our computational simulations
of trabecular and cortical osteoporosis induced by mechanical disuse.