Chemistry Reference
In-Depth Information
OPiv
O
OPiv
PivO
PivO
S
O
S
OPiv
OPiv
PivO
OPiv
26
OPiv
OPiv
PivO
O
O
OPiv
S
S
O
OPiv
S
O
S
PivO
OPiv
PivO
OPiv
PivO
OPiv
OPiv
OPiv
OPiv
28
27
3
-C
3
H
5
)Cl]
2
(1.5 mol%)
Ligand (10 mol%)
CH
2
Cl
2
, BSA, KOAc
[Pd(
η
OAc
CH(COOMe)
2
+ CH
2
(COOMe)
2
Ph
Ph
Ph
Ph
S1
L
26
27
28
% ee
90 (S)
88 (S)
86 (R)
Scheme 10.10
Summary of the best results obtained in the Pd-catalyzed allylic alkylation of
S1
using dithioether ligands
26
-
28.
O
S
S
RO
OR
O
Linker
R:
Sugar
Linker
O
O
O
O
O
HS
SH
O
O
O
O
O
O
O
Me
SH
Ph
HS
D-gluco
D-manno
O
O
O
O
O
O
CH
2
Ph
O
O
O
O
NTCP
HS
SH
D-galacto
D-gluco
SH
SH
NTCP = Tetrachlorophthalimide
Figure 10.13
Dithioether ligand library studied by Khiar and coworkers.
Search WWH ::
Custom Search