Synergistic Solubilization of Mixed Nutraceuticals in Modified Discontinuous Micellar Cubic Structures - Food Colloids: Self-Assembly and Material Science - page 98

remained molecularly solubilized even at levels exceeding 400 ppm. We believe
that the co-solubilization of these two nutraceuticals is a worthwhile achieve-
ment which may have some application advantages.
The microstructural behaviour in the presence of the two guest molecules
was studied using DSC and SAXS measurements with the same thermal
protocols as for the previous systems. Samples containing the two solubilized
molecules exhibited thermal behaviour similar to the Q L phase (Figure 8).
However, close inspection of the effect of lycopene content (100-400 ppm) on
the Q L phase containing 2.5-wt% phytosterols reveals a small temperature shift
in the phase formation upon heating towards higher temperatures with increase
in lycopene content, and a large effect on the transition enthalpy. The trend in
the enthalpy change for the synergistic samples was quite complex and unex-
pected. With 2.5 wt% of phytosterols and all three levels of solubilized lycopene
(100, 200 and 400 ppm), the DH values were higher than for the systems
containing 2.5-wt% phytosterol alone. This means that the lycopene contrib-
utes to improving the internal order of the Q L system. This same trend was also
observed in the cooling scans (results not shown).

Figure 8 (A) The heating curve from the DSC carried out on various samples: (a)

control (without phytosterols or lycopene), (b) 2.5-wt% phytosterols, (c) 2.5-
wt% phytosterols + 100-ppm lycopene, (d) 2.5-wt% phytosterols + 200-ppm
lycopene and (e) 2.5-wt% phytosterols + 400-ppm lycopene. Enthalpy change
D H is plotted against temperature. (B) Expanded plot for heating curve of 2.5
wt% + 100-ppm lycopene