Civil Engineering Reference
In-Depth Information
PLA-based scafolds
MPLA-based scafolds
(
e
)
85.4
100.0
92.3
100
78.7
75
50
25
0
0
5
CNC contents (wt %)
Figure 15.15
Response of hASCss to PLA/CNC and MPLA/CNC nanoi brous scaf olds at er 7 days
of culture. Fluorescence micrographs of stained cells consisting of live (green) and dead (red) cells for
PLA (a), PLA/CNC-5 (b), MPLA (c), and MPLA/CNC-5 (d) scaf olds. Scale bar represents 75 μm;
proliferation viability of cells (e) [229].
Pooyan
et al.
designed a fully biobased i brous porous scaf old consisting of CNCs-
reinforced cellulose acetate propionate (CAP) matrix for potential application in vas-
cular tissue engineering of small diameter grat s. h e resulted scaf old of ered excellent
mechanical performance of about two-fold for 0.2 wt% of CNCs, and almost doubled
for 3 wt% at room temperature [232]. In this way, Pooyan
et al.
designed potential
bioscaf old with oriented microstructures comprising aligned CNCs in cellulose acetate
propionate (CAP), where dispersed CNCs created a rigid percolating network within
the CAP matrix showing considerable mechanical and thermal stability, and substan-
tially enhanced these properties with the alignment of CNCs [233].
Brown
et al.
developed new nanocomposite based on CNCs and i brin demonstrat-
ing potential application for small-diameter replacement vascular grat . h e crosslink-
ing was introduced between i brin and CNCs by periodate oxidation of CNCs, where
periodate oxidation can add reactive carbonyl groups (C = O) on CNCs. In CNCs-
i brin nanocomposites having oxidized CNCs (O-CNCs), i brin provides elasticity and
O-CNCs provide strength to nanocomposites. h e variation of degree of oxidation of
CNCs and the ratio of CNCs-to-i brin resulted in the variation in mechanical strength
and elongation of the nanocomposites. h e nanocomposites with diverse mechanical
