Biology Reference
In-Depth Information
Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.
Blood
99: 102-110
79 Kirito K, Uchida M, Takatoku M, Nakajima K, Hirano T, Miura Y, Komatsu N (1998) A novel
function of Stat1 and Stat3 proteins in erythropoietin-induced erythroid differentiation of a human
leukemia cell line.
Blood
92: 462-471
80 Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, Hennighausen L (1997) Stat5a
is mandatory for adult mammary gland development and lactogenesis.
Genes Dev
11: 179-186
81 Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW (1997)
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression.
Proc Natl Acad Sci USA
94: 7239-7244
82 Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S,
Grosveld G, Ihle JN (1998) Stat5a and Stat5b proteins have essential and nonessential, or redun-
dant, roles in cytokine responses.
Cell
93: 841-850
83 Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF (2001) Ineffective ery-
thropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.
Blood
98:
3261-3273
84 Damen JE, Mui AL, Puil L, Pawson T, Krystal G (1993) Phosphatidylinositol 3-kinase associates,
via its Src homology 2 domains, with the activated erythropoietin receptor.
Blood
81: 3204-3210
85 Damen JE, Cutler RL, Jiao H, Yi T, Krystal G (1995) Phosphorylation of tyrosine 503 in the ery-
thropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI)
3-kinase and for EpR-associated PI 3-kinase activity.
J Biol Chem
270: 23402-23408
86 Klingmuller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF (1997)
Identification of a novel pathway important for proliferation and differentiation of primary ery-
throid progenitors.
Proc Natl Acad Sci USA
94: 3016-3021
87 von Lindern M, Amelsvoort MP, van Dijk T, Deiner E, van Den Akker E, van Emst-De Vries S,
Willems P, Beug H, Lowenberg B (2000) Protein kinase C alpha controls erythropoietin receptor
signaling.
J Biol Chem
275: 34719-34727
88 Barnache S, Mayeux P, Payrastre B, Moreau-Gachelin F (2001) Alterations of the phosphoinosi-
tide 3-kinase and mitogen-activated protein kinase signaling pathways in the erythropoietin-inde-
pendent Spi-1/PU.1 transgenic proerythroblasts.
Blood
98: 2372-2381
89 Moreau-Gachelin F, Wendling F, Molina T, Denis N, Titeux M, Grimber G, Briand P, Vainchenker
W, Tavitian A (1996) Spi-1/PU.1 transgenic mice develop multistep erythroleukemias.
Mol Cell
Biol
16:2453-2463
90 Kashii Y, U c hida M, Kirito K, Tanaka M, Nishijima K, Toshima M, Ando T, Koizumi K, Endoh
T, Sawada K et al. (2000) A member of Forkhead family transcription factor, FKHRL1, is one of
the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythro-
poietin signal transduction.
Blood
96: 941-949
91 Haseyama Y, Sawada K, Oda A, Koizumi K, Takano H, Tarumi T, Nishio M, Handa M, Ikeda Y,
Koike T (1999) Phosphatidylinositol 3-kinase is involved in the protection of primary cultured
human erythroid precursor cells from apoptosis.
Blood
94: 1568-1577
92 Verdier F, Chretien S, Billat C, Gisselbrecht S, Lacombe C, Mayeux P (1997) Erythropoietin
induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for ery-
thropoietin-induced phosphatidylinositol 3-kinase activation.
J Biol Chem
272: 26173-26178
93 Kubota Y, Tanaka T, Kitanaka A, Ohnishi H, Okutani Y, Waki M, Ishida T, Kamano H (2001) Src
transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase.
EMBO J
20: 5666-5677
94 Bao H, Jacobs-Helber SM, Lawson AE, Penta K, Wickrema A, Sawyer ST (1999) Protein kinase
B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in
HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant
subclone (HCD57-SREI cells).
Blood
93: 3757-3773
95 Henry M, Lynch J, Eapen A, Quelle FW (2001) DNA damage-induced cell-cycle arrest of
hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway.
Blood
98: 834-841
96 Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ (2001) Akt1/PKB
is required for normal
growth but dispensable for maintenance of glucose homeostasis in mice.
J Biol Chem
276:
38349-38352
97Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS,
Shulman GI, Birnbaum MJ (2001) Insulin resistance and a diabetes mellitus-like syndrome in
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