Biology Reference
In-Depth Information
Glossary and abbreviations
AAV
adeno-associated virus
ACD
anemia of chronic disease
ACE
angiotensin-converting enzyme
AIDS
acquired immunodeficiency syndrome
ATII
angiotensin II
AT1R
ATII type-1 receptor
AUC
area under the serum concentration time curve, estimated by
integration (generally by use of trapezoidal rule) from time
zero to the last collection point (AUC
(0-t)
) with extrapolation
to infinity where possible (AUC
(0-inf)
)
BFU-E
erythroid burst-forming unit
BHK
baby hamster kidney
BNDF
brain-derived neurotrophic factor
CAD
carboxyl-terminal transactivation domain
CAS
Court of Arbitration for Sport
CBER
Center for Biologics Evaluation and Research
CDER
Center for Drug Evaluation and Research
CDK
cyclin-dependent kinase
CFR
Code of Federal Regulations
CFU
colony-forming unit
CFU-E
erythroid colony-forming unit
CFU-GEMM
granulocyte-macrophase, erythrocyte, macrophage,
megakaryocyte colony-forming unit
CGMP
Current Good Manufacturing Processes
CHO
Chinese hamster ovary
CL
clearance from the central compartment, estimated from
AUC
(0-infinity)
/Dose
maximum observed concentration
C
max
DEAE
diethylaminoethyl
DHFR
dihydrofolate reductase
EGF
epidermal growth factor
ELISA
enzyme-linked immunosorbent assay
EMP
erythropoietin mimetic protein
EPO
erythropoietin
EPOR
receptor for erythropoietin
