Biology Reference
In-Depth Information
28 Dennis JW, Granovsky M, Warren CE (1999) Protein glycosylation in development and disease.
Bioessays
21: 412-421
29 Elliott S, Chang D, Delorme E, Dunn C, Egrie J, Giffin J, Lorenzini T, Talbot C, Hesterberg L
(1996) Isolation and characterization of conformation sensitive antierythropoietin monoclonal
antibodies: Effect of disulfide bonds and carbohydrate on recombinant human erythropoietin
structure.
Blood
87: 2714-2722
30 Elliott S, Lorenzini T, Chang D, Barzilay J, Delorme E, Giffin J, Hesterberg L (1996) Fine-struc-
ture epitope mapping of anti-erythropoietin monoclonal antibodies reveals a model of recombi-
nant human erythropoietin structure.
Blood
87: 2702-2713
31 Macdougall IC, Gray SJ, Elston O, Breen C, Jenkins B, Browne J, Egrie J (1999)
Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dial-
ysis patients.
J Am Soc Nephrol
10: 2392-2395
32 Nissenson AR (2001) Novel erythropoiesis stimulating protein for managing the anemia of chron-
ic kidney disease.
Am J Kidney Dis
38: 1390-1397
33Nissenson AR, Swan SK, Lindberg JS, Soroka SD, Beatey R, Wang C, Picarello N, McDermott-
Vitak A, Maroni BJ (2002) Randomized, controlled trial of darbepoetin alfa for the treatment of
anemia in hemodialysis patients.
Am J Kidney Dis
40: 110-118
34 Smith R (2002) Applications of darbepoetin-[alpha], a novel erythropoiesis-stimulating protein, in
oncology.
Curr Opinion Hematol
9: 228-233
35 Narhi LO, Arakawa T, Aoki KH, Elmore R, Rohde MF, Boone T, Strickland TW (1991) The effect
of carbohydrate on the structure and stability of erythropoietin.
J Biol Chem
266: 23022-23026
36 Endo Y, Nagai H, Watanabe Y, Ochi K, Takagi T (1992) Heat-induced aggregation of recombinant
erythropoietin in the intact and deglycosylated states as monitored by gel permeation chromatog-
raphy combined with a low-angle laser light scattering technique.
J Biochem
112: 700-706
37Jelkmann W (1992) Erythropoietin: Structure, control of production, and function.
Physiol Rev
72:
449-489
38 Lis H, Sharon N (1993) Protein glycosylation. Structural and functional aspects.
Eur J Biochem
218: 1-27
39 Macdougall IC (2002) Darbepoetin alfa: A new therapeutic agent for renal anemia.
Kidney Int
61:
S55-S61
40 Delgado C, Francis GE, Fisher D (1992) The uses and properties of PEG-linked proteins.
Crit Rev
Ther Drug Carrier Syst
9: 249-304
41 Francis GE, Fisher D, Delgado C, Malik F, Gardiner A, Neale D (1998) PEGylation of cytokines
and other therapeutic proteins and peptides: The importance of biological optimisation of coupling
techniques.
Int J Hematol
68: 1-18
42 Goodson RJ, Katre NV (1990) Site-directed pegylation of recombinant interleukin-2 at its glyco-
sylation site.
Biotechnology
8: 343-346
43 He XH, Shaw PC, Tam SC (1999) Reducing the immunogenicity and improving the
in vivo
activ-
ity of trichosanthin by site-directed pegylation.
Life Sci
65:355-368
44 Weich NS, Tullai J, Guido E, McMahon M, Jolliffe LK, Lopez AF, Vadas MA, Lowry PA ,
Quesenberry PJ, Rosen J (1993) Interleukin-3/erythropoietin fusion proteins:
In vitro
effects on
hematopoietic cells.
Exp Hematol
21: 647-655
45 Coscarella A, Carloni C, Liddi R, Mauro S, Novelli S, Mele A, Masella B, Valtieri M, De Santi R
(1997) Production of recombinant human GM-CSF-EPO hybrid proteins:
In vitro
biological char-
acterization.
Eur J Haematol
59: 238-246
46 Sytkowski AJ, Lunn ED, Davis KL, Feldman L, Siekman S (1998) Human erythropoietin dimers
with markedly enhanced
in vivo
activity.
Proc Natl Acad Sci USA
95: 1184-1188
47Dalle B, Henri A, Rouyer-Fessard P, Bettan M, Scherman D, Beuzard Y, Payen E (2001) Dimeric
erythropoietin fusion protein with enhanced erythropoietic activity
in vitro
and
in vivo
.
Blood
97:
3776-3782
48Sytkowski AJ, Lunn ED, Risinger MA, Davis KL (1999) An erythropoietin fusion protein com-
prised of identical repeating domains exhibits enhanced biological properties.
J Biol Chem
274:
24773-24778
49 Coscarella A, Liddi R, Di Loreto M, Bach S, Faiella A, van der Meide PH, Mele A, De Santis R
(1998) The rhGM-CSF-EPO hybrid protein MEN 11300 induces anti-EPO antibodies and severe
anaemia in rhesus monkeys.
Cytokine
10: 964-969
50 Cerami A, Brines M, Ghezzi P, Cerami C, Itri LM (2002) Neuroprotective properties of epoetin
alfa.
Nephrol Dial Transplant
17: Suppl-12