Biology Reference
In-Depth Information
Table 6. Pharmacokinetic parameters for rHuEPO in naive pediatric patients with chronic renal failure
Ref
Route Age (yr)
n
Dose (U/kg)
Parameter estimates
CL
T
max
F
t
1/2,z
(hr)
(hr)
(mL/hr/kg)(%)
[38]
SC
[1.8-10.4]
5
100
12-24
NA
NA
NA
[epoetin beta]
[38]
IP
[0.6-12.5]
8
100 in 20mL/kg
12
NA
NA
42
a
dialysis fluid
[epoetin beta]
[38]
IP
[3.3-14.1]
8
100 in 50mL
12
NA
NA
88
a
dialysis fluid
[epoetin beta]
[39]
IV
[9-16]
9
40
NA
5.63
10.1
NA
[epoetin beta]
[4.39-
[7.07-
6.86]
14.9]
[39]
SC
[9-16]
9
40
10
14.9
b
NA
40
[epoetin beta]
[6.24-
[20-64]
51.7]
IP
NA
10.7
NA
[39]
3
40
14
17
[epoetin beta]
[8.75-14.1]
[9.6-28]
[40]
SC
[0.25-18]
15
25
9
25.2
17.7
c
NA
[epoetin alfa]
[6.2-
[3.4-
58.7]
43.5]
[41]
SC
[6.8-19.9]
20
4000 U/m
2
14.3
14.3
NA
34
d
(133 U/kg)
(9.4)
(7.2)
[epoetin alfa]
[41] V
e
15
4000 U/m
2
NA
10.85
6
f
2
NA
(133 U/kg)
[10.8-
[4.76-
[epoetin alfa]
10.9]
7.14]
[42] V
NA
10.4
0.63
g
3
NA
[8-14]
[9-17]
[1-24]
NA
NA
NA
[42]
SC
3
100
[43]
SC
11.62 (1.42)
8
50
18.5
13.3
NA
NA
[epoetin alfa]
(SEM 2.6) (SEM 1.9)
[43]
12.75 (0.6)
8
50
26.8
13.5
NA
34
h
CAPD
[epoetin alfa]
(SEM 7.7) (SEM 3)
[44]
IV
[7-18]
8
50 (1
st
dose)
NA
7.5 (0.9)
NA
NA
[epoetin alfa]
[6.2-8.7]
IV
3
50 (7
th
dose)
NA
4.5
i
(0.1) NA
NA
[44]
[epoetin alfa]
[45]
IP
9.1 (5.1)
10
100 in 50mL
12
21.1
j
NA
NA
(non-naive)
dialysate
[epoetin alfa]
[46]
SC
13.5 [9-18]
10
75
No difference in presence or
[epoetin alfa]
absence of EMLA cream
