Experimental design application and interpretation in pharmaceutical technology - Computer-Aided Applications in Pharmaceutical Technology - page 54

Response surface plot showing effect of
chitosan and sodium alginate concentration
on encapsulation effi ciency (reprinted from
Motwani et al., 2008; with permission
of Elsevier)

Figure 3.4

constructed and used for generation of regression equation
accounting for linear and quadratic factor effects, as well as for
factor interactions. The Box-Behnken experimental design
facilitated the optimization of a muco-adhesive nano-particulate
carrier systems for prolonged ocular delivery of the drug.

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3.4 References

Armstrong, A.N. (2006) Pharmaceutical Experimental Design and Interpretation ,
2nd edition. Boca Raton, FL: CRC Press, Taylor & Francis Group.
Box, G.E.P. and Behnken, D.W. (1960) 'Simplex sum designs: a class of second
order rotatable designs derivable from those of fi rst order', Ann. Math.
Stat. , 31: 838-64.