Experimental design application and interpretation in pharmaceutical technology - Computer-Aided Applications in Pharmaceutical Technology - page 31

3

Experimental design application
and interpretation in
pharmaceutical technology

Jelena Djuris, Svetlana Ibric, and Zorica Djuric,
Department of Pharmaceutical Technology
and Cosmetology, Faculty of Pharmacy,
University of Belgrade

Abstract: This chapter provides a basic theoretical background on
experimental design application and interpretation. Techniques
described include screening designs, full and fractional factorial
designs, Plackett-Burman design, D-optimal designs, response surface
methodology, central composite designs, Box-Behnken design, and
mixture designs, etc. The reader will be introduced to the experimental
domains covered by specifi c design, making it easier to select the one
appropriate for the problem. After theoretical introduction, a number
of illustrative examples of design of experiments application in the
fi eld of pharmaceutical technology are presented.

￿

￿ ￿

Key words: design of experiments, screening designs, full and
fractional factorial designs, response surface methodology, mixture
designs.

3.1 Introduction

Experimental design is a concept used to organize, conduct, and interpret
results of experiments in an effi cient way, making sure that as much