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Computer-aided formulation
development
Ljiljana Djekic, Dragana Vasiljevic, and
Marija Primorac, Department of
Pharmaceutical Technology and
Cosmetology, Faculty of Pharmacy,
University of Belgrade
Abstract:
This chapter introduces the concept of formulation
development assisted by computer applications. Development and
optimization of various types of pharmaceutical emulsions
microemulsions, self-microemulsifying systems, and double
emulsions are presented. Illustrative examples are presented to
demonstrate the ability of computer-aided tools to facilitate
formulation development. Various techniques, such as design of
experiments and artifi cial neural networks, are implemented for
optimization of the formulation and/or processing parameters.
Furthermore, some of the critical quality attributes and processing
parameters are optimized simultaneously. The examples presented
should serve as the foundation for the future quality-by-design
development of pharmaceutical emulsion and (self) microemulsion
formulations.
Key words:
pharmaceutical emulsions, microemulsions, self-
microemulsifying drug delivery systems (SMEDDS), double
emulsions, formulation, optimization.
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