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7
Computational fl uid dynamics:
applications in
pharmaceutical technology
Ivana Masic, Jelena Parojcic, and Zorica Djuric,
Department of Pharmaceutical Technology and
Cosmetology, Faculty of Pharmacy, University of
Belgrade
Abstract: This chapter introduces the concept of computational
fl uid dynamics (CFD) and its applications in pharmaceutical
technology. Basic theoretical explanations on the mathematics of
fl uid fl ow and numerical grids are provided. CFD is a versatile tool
that is mainly used in complex dynamical process characterization.
Examples of CFD applications in development of inhalers, analysis
of dissolution apparatus hydrodynamics, and fl uidized bed process
simulations are presented.
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Key words: Computational fl uid dynamics (CFD), numerical grids,
fl uid fl ow, inhalers, dissolution apparatus hydrodynamics, fl uid bed
processes.
7.1 Introduction
Fluid mechanics studies fl uid performance at rest and in motion. It can
be divided into: fl uid statics , the study of fl uids at rest; fl uid kinematics ,
the study of fl uid in motions; and fl uid dynamics , which deals with the
 
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