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new information regarding drug biopharmaceutical properties being
collected, it is expected that GI modeling will be more often used by
formulation scientists. In this context, it should be stressed that large
amounts of valuable data on drug biopharmaceutical properties still lie
within pharmaceutical companies and regulatory agencies, and even
partial access to these data would be helpful to generate and/or validate
in silico absorption models. Published examples of the successful
application of in silico techniques would also assist in promoting their
wider acceptance.
6.10 References
Abuasal, B.S., Bolger, M.B., Walker, D.K., and Kaddoumi, A. (2012) ' In silico
modeling for the nonlinear absorption kinetics of UK-343,664: a P-gp and
CYP3A4 substrate', Mol. Pharm. , 9(3): 492-504.
Aburub, A., Risley, D.S., and Mishra, D. (2008) 'A critical evaluation of fasted
state simulating gastric fl uid (FaSSGF) that contains sodium lauryl sulfate and
proposal of a modifi ed recipe', Int. J. Pharm. , 347(1-2): 16-22.
Agoram, B., Woltosz, W.S., and Bolger, M.B. (2001) 'Predicting the impact of
physiological and biochemical processes on oral drug bioavailability', Adv.
Drug Deliv. Rev. , 50(Suppl 1): S41-67.
Al-Salami, H., Butt, G., Tucker, I., and Mikov, M. (2008) 'Infl uence of the
semisynthetic bile acid (MKC) on the ileal permeation of gliclazide in healthy
and diabetic rats', Pharmacol. Rep. , 60(4): 532-41.
Al-Salami, H., Butt, G., Tucker, I., Fawcett, P. , Golocorbin-Kon, S., et al. (2009)
'Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats',
Eur. J. Drug Metabol. Pharmacokinet. , 34(1): 43-50.
Amidon, G.L., Lennernas, H., Shah, V. P. , and Crison, J.R. (1995) 'A theoretical
basis for a biopharmaceutic drug classifi cation: the correlation of in vitro drug
product dissolution and in vivo bioavailability', Pharm. Res. , 12(3): 413-20.
Bauer, L.A. (2008) 'Carbamazepine', In L.A. Bauer (ed.) Applied Clinical
Pharmacokinetics , 2nd edition, pp. 548-62. New York: McGraw Hill
Medical.
Bernareggi, A. (1998) 'Clinical pharmacokinetics of nimesulide', Clin.
Pharmacokinet. , 35(4): 247-74.
Boobis, A., Gundert-Remy, U., Kremers, P. , Macheras, P. , and Pelkonen, O.
(2002) ' In silico prediction of ADME and pharmacokinetics. Report of
an expert meeting organized by COST B15', Eur. J. Pharm. Sci. , 17(4-5):
183-93.
Cloe ® PK Pharmacokinetic prediction using PBPK modeling Cloe ® HIA Prediction
of human intestinal absorption . Available at: http://www.cyprotex.com/
(accessed 3 June 2012).
Crison, J.R., Timmins, P. , Keung, A., Upreti, V. V. , Boulton, D.W., and Scheer, B.J.
(2012) 'Biowaiver approach for Biopharmaceutics Classifi cation System class
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