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(a) Virtual GLK dissolution profi les, and (b) the
corresponding simulated
in vivo
profi les, along with
the actual
in vivo
data (from Najib et al., 2002) (the
simulated profi les b, c, and d overlap)
Figure 6.12
differences observed
in vitro
were less pronounced in the predicted PK
profi les (the simulated profi les b, c, and d overlapped). The highest degree
of deviation from the
in vivo
observed profi le was demonstrated for
profi le a, representing a scenario in which less than 85% of the drug is
dissolved. On the other hand, values of the slope close to unity, as well
as high coeffi cients of correlation, indicated the presence of a level A
correlation for the profi les b, c, d, and e.
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