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(a) Virtual GLK dissolution profi les, and (b) the
corresponding simulated in vivo profi les, along with
the actual in vivo data (from Najib et al., 2002) (the
simulated profi les b, c, and d overlap)
Figure 6.12
differences observed in vitro were less pronounced in the predicted PK
profi les (the simulated profi les b, c, and d overlapped). The highest degree
of deviation from the in vivo observed profi le was demonstrated for
profi le a, representing a scenario in which less than 85% of the drug is
dissolved. On the other hand, values of the slope close to unity, as well
as high coeffi cients of correlation, indicated the presence of a level A
correlation for the profi les b, c, d, and e.
 
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