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Parameter sensitivity analysis: dependence of fraction
CBZ absorbed on different input parameters (the
center of the
x
-axis for each of the parameters tested
represents the value that was used in the simulations)
Figure 6.8
input value), and PSA for drug dose indicated that single doses up to
1200 mg would not impair the extent of CBZ absorption (Figure 6.8).
In another case where CBZ was used as the model drug (Zhang et al.,
2011), PSA was performed for parameters for which accurate data were
not available and the selected formulation parameters, including mean
particle radius, particle radius standard deviation, drug particle density,
diffusion coeffi cient, dose volume, drug permeability, drug solubility,
precipitation time, and four Weibull parameters were used to describe
release profi le of the XR formulations. Four dosage forms of CBZ (IR
suspension, IR tablet, XR tablet, and XR capsule), under both fasted and
fed conditions, were studied. PSA results for solubility indicated that
drug
in vivo
solubility had a signifi cant impact on PK profi les when it was
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